서브비주얼

Keynote Speakers

Day 2 (July 4, 2025)

Opening

Welcoming remarks

  • Hyun-Young Park

    Director General,
    Korea National Institute of Health, KDCA

    Education

    • 2000 Yonsei University College of Medicine (Ph.D.)
    • 1995 Yonsei University College of Medicine (M.S.)
    • 1990 Yonsei University College of Medicine (M.D.)

    Experience

    • 2023 ~ Present Director, Korea National Institute of Health
    • 2020 ~ 2023 Director, Department of Precision Medicine, KNIH
    • 2018 ~ 2020 Director, Center for Genome Science, KNIH
    • 2017 ~ 2018 Director, Division of Cardiovascular Diseases, KNIH, KCDC
    • 2012 ~ 2023 PI, National Research Program for Women’s Health
    • 2011 ~ 2014 Team leader, National Center for Medical Information and Knowledge TF
    • 2008 ~ 2014 Team leader, Clinical Research Coordination TF
    • 2005 ~ 2017 Director, Division of Cardiovascular & Rare Diseases, KNIH, KCDC
    • 2002 ~ 2003 Research Associate, Duke University Medical Center, USA
    • 2004 ~ 2002 Assistant professor of Cardiology (Dept. of internal medicine)
    • 2000 ~ 2005 Assistant professor of Cardiology (Dept. of internal medicine)
    • 1998 ~ 2000 Assistant professor, Yonsei Cardiovascular Research Institute
    • 1998 ~ 2000 Instructor, Yonsei Cardiovascular Research Institute, Yonsei University College of Medicine
    • 1996 ~ 1998 Research Student, Department of Clinical Pathology, Shimane Medical University, Japan
    • 1995 ~ 1996 Research fellow, Cardiology division, Yonsei Cardiovascular Center, Yonsei University College of Medicine
    • 1990 ~ 1995 Resident, Department of Internal Medicine, Yongdong Severance Hospital
  • Opening remarks

    Hee-Chang Jang

    Director,
    Korea National Institute of Infectious Diseases, KNIH, KDCA

    Education

    Experience

  • Congratulatory Remarks

    Hani Kim

    Executive Director, RIGHT Foundation

    Education

    Experience

Session 1. Vaccine R&D and current status for pandemic preparedness and response

Chair

  • Baek-Lin Sung

    Professor, Yonsei University

    Education

    • 1982 ~ 1987 PhD, Massachusetts Institute of Technology (Biology)
    • 1977 ~ 1979 MS, KAIST (Biological Engineering)
    • 1973 ~ 1977 BS, Seoul National University (Pharmacy)

    Experience

    • 2020 ~ Present Director General, Vaccine Innovative Technology ALliance (VITAL)-Korea
    • 2023 ~ Present Chairman, Korea Advanced Center for Vaccine Development (KAVAD)
    • 2022 ~ 2024 Chair, Division of Biotechnology, Science & Technology Advisory Board, Ministry of Foreign Affairs (MoFA), Korean Government
    • 2022 ~ 2023 Chair, Infectious Disease R&D Organizations Council
    • 2020 ~ 2023 Chair, COVID-19 Vaccine Pan-Government Strategic Plan, Korean Government
    • 2021 ~ 2023 Member, Presidential Advisory Council of Science and Technology (PACST)
    • 2013 ~ 2018 Director, Vaccine Translational Research Center
    • 2001 ~ 2009 CEO, Protheon
    • 1999 ~ 2002 Representative, Ad Hoc Group Meeting, Biological Weapons Convention (BWC) UN Conference
    • 1998 ~ 2020 Professor, Department of Biotechnology, Yonsei Univ
    • 1993 ~ 1998 Director, Institute of Biological Sciences, Hanhyo Institute of Technology
    • 1992 ~ 1993 Scientist, Aviron, USA
    • 1988 ~ 1992 Post-doc, University of Oxford, UK
    • 1979 ~ 1982 Scientist, Korea Institute of Science and Technolog
  • Hun-Sang Lee

    CSO, RIGHT Foundation

    Education

    • 1995 ~ 2000 University of Chicago (BA in Economics)
    • 2001 ~ 2008 Yonsei University College of Medicine (MD)
    • 2009 ~ 2010 Johns Hopkins School of Public Health (MPH)
    • 2013 ~ 2021 Yonsei University College of Medicine, Health Ethics and Law Division (PhD)

    Experience

    • 2022 ~ Present CSO, RIGHT Foundation
    • 2017 ~ Present Adjunct Professor, Yonsei University School of Public Health
    • 2013 ~ Present Member of the Board, Korea Society of Global Health
    • 2019 ~ 2022 Representative Partner, Global Health & Development Partners (GHDP)
    • 2011 ~ 2016 Health Advisor, KOICA HQ and Ghana Country Office
    • 2008 ~ 2009 Medical Officer in Division of National Immunization Program, Korea CDC

Speaker

  • Jerome H. Kim

    Director General, International Vaccine Institute

    Topic

    • Rethinking bacterial vaccines in an age of antimicrobial resistance and climate change

    Summary

  • Jie-Oh Lee

    Professor, Pohang University or Science and Technology

    Topic

    • Cryo-EM Based Structural and Biophysical Characterization of Vaccine Antigens for Infectious Diseases

    Summary

    • Stabilizing the pre-fusion structures of antigenic proteins can enhance the effectiveness of antiviral vaccines. The pre-fusion form of hemagglutinin (HA) from the influenza virus typically adopts a stable trimeric structure. However, the recombinant ectodomain of HA from the A/California/04/2009 (H1N1) influenza virus formed a monomer in solution rather than the expected trimer. To promote trimer formation in the pre-fusion conformation, we redesigned five amino acid residues in the stem region of HA that are involved in trimerization. The engineered HA protein formed a stable trimer at both pH 8.0 and pH 5.5. Additionally, the thermal stability of the modified protein improved, as indicated by an approximately ten-degree increase in its denaturation temperature. Cryo-EM analysis at 2.2 Å resolution confirmed that the mutant HA protein adopted the pre-fusion structure. We applied the same optimization strategy to the HA proteins from A/Malaysia/1706215/2007 (H1N1) and A/swine/Hong Kong/2106/98 (H9N2). These engineered proteins exhibited enhanced thermal stability and maintained a trimeric pre-fusion structure, as confirmed by cryo-EM analysis. Furthermore, applying this optimization strategy to the equivalent five residues in hemagglutinins from six additional group 1 influenza viruses successfully stabilized their trimeric structures. Our research suggests that once a set of suboptimal residues is experimentally identified in advance, rapid redesign of HA sequences from novel viral strains, even with significant sequential variation, is feasible using computational tools like the protein MPNN program. The computational calculation can be achievable within hours with moderate computational resources. Therefore, our method can be a strategic response to emerging influenza strains with unexpected sequential variations. Continuous efforts to identify multiple sets of key mutational sites will further enhance readiness for future outbreaks of influenza and other zoonotic viruses.
  • Matae Ahn

    Clinician Scientist, Nanyang Technology University

    Topic

    • Bat-inspired new targets to fight human infectious diseases and beyond

    Summary

    • Bats are attracting the highest attention as a putative origin of SARS-CoV-2 responsible for the COVID-19 pandemic. Although less known to the public, bats have several unique features with high value to human health. These include asymptomatically hosting many viruses lethal to humans and their exceptionally long lifespan (and healthspan). Our mission is to uncover what makes them special. One of the key lessons learnt is that they have naturally evolved to dampen inflammation and protect themselves from inflammatory diseases, via controlling the inflammasome pathway tightly (Nat Micro 2019, PNAS 2020, Nature 2021, Cell 2023). This work has led to patents that could lead to a new class of anti-inflammatory drugs and were licensed to a bat biotech company for commercialization in 2023. In addition, studying the human serological responses to coronaviruses originated from bats has led to our new vaccine and therapeutic strategies with a broad-spectrum effect for sarbecoviruses (NEJM 2021). The in-depth research into the natural mechanisms of disease resistance and healthy longevity in bats can help us fight human diseases including infectious diseases and beyond. In this presentation, I will share some of the key bat-inspired lessons and my approaches to uncovering more bat-inspired novel targets and strategies to fight human diseases using the established disease-free bat models.
  • Nakorn Premsri

    Director, National Vaccine Institute

    Topic

    • Thailand’s Vaccine strategies for pandemic Preparedness

    Summary

Session 2. Therapeutics Development and international network for emerging virus

Chair

  • Ki-Soon Kim

    Professor, Korea University

    Education

    • 1984 ~ 1988 B.S. / Department of Biology, College of Natural Science, Korea University, Seoul Korea
    • 1988 ~ 1990 M.S. / Department of Biology, College of Natural Science, Korea University Graduate School, Seoul Korea
    • 1994 ~ 2000 Ph.D. / Department of Life Science, College of Natural Science, Chung-Ang University, Seoul Korea

    Experience

    • 2022 ~ Present Advisory member of Infectious Disease Policy Beauro, Seoul Metropolitan city, Korea
    • 2022 ~ Present Committee member of Government-wide R&D Fund for Infectious Disease Research (GFID), Korea
    • 2021 ~ Present Advisory member of Korea Pest Control Association, Korea
    • 2006 ~ Present Full member, The American Society for Virology
    • 1990 ~ Present Committee member, The Korean Society of Virology
    • 1990 ~ 2019 Director, Researcher, Divisions of Influenza and respiratory viruses, Department of Virus Research, National Institute of Health, Korea
    • 2004 ~ 2006 University of Nebraska Medical Center, NE, USA, Visiting Scientist
    • 1996 ~ 1997 Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, Visiting Scientist
    • 1994 ~ 1994NIID, Tokyo, Japan, “Polio Eradication Program”, WHO fellow
  • Jin-Jong Myung

    Professor, Jeonbuk National University

    Education

    • 2000 ~ 2006 PhD, Northwestern University Medical School
    • 1996 ~ 1999 MSc, Seoul National University
    • 1990 ~ 1996 BSc, Seoul National University

    Experience

    • 2013 ~ Present 전북대학교 (인수공통전염병연구소)
    • 2011 ~ 2013 Presidential Postdoc, Novartis Institutes for Biomedical Research (NIBR)
    • 2007 ~ 2011 Postdoc, University of California San Francisco

Speaker

  • Timothy Sheahan

    Professor, University of North Carolina at Chapel Hill

    Topic

    • Preparing for tomorrow’s pandemics today through the development of broadly active therapies

    Summary

  • Hee-Young Lim

    Senior staff scientist, Korea National Institute of Infectious Diseases

    Topic

    • Research on therapeutics development to emerging high-risk viruses

    Summary

  • Ana Liza H. Duran

    Director, Research Institute for Tropical Medicine (RITM)

    Topic

    • Collaboration on infectious disease research using overseas research centers in the Philippines

    Summary

    • In our continuous effort to foster international cooperation for infectious disease research, the Philippines Research Institute for Tropical Medicine (RITM) and the Korea National Institute of Infectious Diseases (KNIID) signed a Memorandum of Understanding (MOU) last July 20, 2023. This agreement formalized the establishment of an overseas research hub in the Philippines, initiated by KNIID, where both institutions will maximize their strengths and resources. The primary objectives of this research hub are to enhance infectious disease studies by:
      1. Conducting cutting -edge research and development that aims to leverage advanced methodologies and technologies, such as genomics, data analytics, and field epidemiology to enhance our understanding of infectious diseases;
      2. Fostering collaborations among researchers, industry partners, academic institution and other stakeholders;
      3. Identifying and securing funding and resources necessary to support both on going and futures research activities;
      4. Facilitating and dissemination of research findings for the benefit of public health, and;
      5. Providing training and development opportunities for researchers and students by fostering a culture of continuous learning.
  • Sazaly Bin Abu Bakar

    Director/Professor, TIDRIC/University of Malaya

    Topic

    • Therapeutic development and international collaboration as a strategy for future pandemic preparedness and response at TIDREC

    Summary

    • Tick-borne viral diseases ; An emering, Under-Appreciated Threat?

Session 3: Zoonotic infectious diseases, solution through one-Health approach R&D

Chair

  • Dong-Min Kim

    Professor, Chosun University

    Education

    • 2003 ~ 2005 Chosun University Bachelor
    • 1997 ~ 1999 Chosun University Master
    • 1989 ~ 1995 Chosun University Ph.D

    Experience

    • 2013 ~ Present Professor, Chosun University
    • 2010 ~ 2012 Training at the US Centers for Disease Control and Prevention (CDC)
    • 2010 ~ 2013 Associate Professor, Chosun University
    • 2006 ~ 2010 Assistant Professor, Chosun University
    • 2004 ~ 2006 Full-time lecturer at Chosun University
    • 2003 ~ 2004 Seoul National University Hospital Resident
    • 2000 ~ 2002 Jeonnam Provincial Office Epidemiological Investigator
  • Keun-Hwa Lee

    Professor, Hanyang University

    Education

    • 2017 ~ Present MSc Infectious Diseases Course International Programmes in LONDON SCHOOL of HYGIENE & TROPICAL MEDICINE(LSHTM), UOL, London UK
    • 2000 ~ 2003 Ph.D. in Microbiology and Immunology Seoul National University College of Medicine, Seoul South Korea.
    • 1994 ~ 1999 M.S. in Microbiology Kyungpook National University College of Science, Daegu South Korea
    • 1990 ~ 1994 B.S. in Microbiology Kyungpook National University College of Science, Daegu South Korea

    Experience

    • 2020 ~ Present rofessor Department of Microbiology Hanyang University College of Medicine, Seoul South Korea
    • 2004 ~ 2020 Assistant Professor, Associate Professor, and Professor Department of Microbiology and Immunology Jeju National University College of Medicine, Jeju South Korea
    • 2015 ~ 2015>
      2020 ~ Present
      Visiting Scientist US Army Medical Component-Armed Forces Research Institute of Medical Sciences(AFRIMS) in Bangkok Thailand
    • 2014 ~ 2014 Surveillance officer and International Health Regulation (IHR) duty officer(Volunteer, sabbatical year) The Emer- ging Diseases Surveillance and Response(ESR) World Health Organization, Regional Office for the Western Pacific(WPRO) in Manila Philippines
    • 2005 ~ 2006 Research fellow Channing Lab. BWH, Harvard Medical School, Boston MA USA
    • 2003 ~ 2004 BK21 Postdoc. Department of Microbiology and Immunology Seoul National University College of Medicine, Seoul South Korea
    • 2001 ~ 2003 Teaching Assistant Department of Microbiology and Immunology Seoul National University College of Medicine, Seoul South Korea
    • 1994 ~ 1997 1st lieutenant Republic of Korea Airforce

Speaker

  • Byung-Hwa Jeon

    Professor, University of Minnesota

    Topic

    • Strategic vaccination of food-producing animals: A one health strategy for mitigating infectious disease transmission

    Summary

    • Large-scale food production is common in the U.S., leading to extensive interactions between the environment and food animals. Since the major foodborne pathogens in the U.S., such as Campylobacter and Salmonella, originate from animals, these pathogens enter the food supply chain from animal reservoirs. This underscores the critical connection between food safety and the One Health approach, which integrates human, animal, and environmental health. To mitigate the risk of microbial contamination from these zoonotic pathogens, U.S. regulatory agencies encourage producers to implement comprehensive pre-harvest interventions. For instance, the USDA promotes non-antibiotic strategies, such as vaccination, to reduce pathogen loads in food animals before slaughter. In Europe and Japan, successful reductions in Salmonella infections have been achieved through poultry vaccination. However, effective pre-harvest methods for Campylobacter are currently lacking. Our laboratory has recently developed a live-attenuated Campylobacter vaccine that significantly reduces the bacterial loads in poultry, demonstrating promising potential as an effective pre-harvest intervention strategy.
  • Nguyen Le Khanh Hang

    Deputy Head, National Institute of Hygiene and Epidemiology(NIHE)

    Topic

    • Situation of Viral Zoonotic Diseases in Vietnam

    Summary

  • Jang-Won Yoon

    Professor, Kangwon University

    Topic

    • Domestic response and research direction for human-animal One Health system infectious diseases

    Summary

    • Enteropathogenic Escherichia coli(EPEC) is one of many pathogenic E. coli types, and is associated with infantile diarrhea in both human and domestic animals. Colonization of the small intestine is essential for pathogenesis of EPEC, and this is achieved via complex regulation of virulence factors interacting at the gastrointestinal tract (GIT). The mechanism behind this regulation is bacterial stringent response, an adaptive response against diverse host environmental stress including nutrient depletion. Stringent response is mediated by the concentration of an intracellular alarmone guanosine tertraphosphate (ppGpp). Since ppGpp controls the affinity of RNA polymerase toward promoters, a change in its level has a pleiotropic effect on bacterial genes, such as genes involved in metabolism and virulence. However, the role of ppGpp-mediated signaling in the pathogenesis of EPEC is not well understood. In this study, a ppGpp-defective (ppGpp0) mutant o fthe EPEC2348/69 strain was created and its phenotypic effects were further characterized. Our experimental analyses demonstrated that a ppGpp0 EPEC (i) derepressed the expression of type IV bundle forming pilus (BFP), (ii) repressed the glutamate decarboxylase (GAD)- dependent acid resistance system, (iii) down-regulated the locus of enterocyte effacement (LEE) pathogenicity island encoding a functional type III secretion system (T3SS), (iv) was unable to induce the EPEC-mediated killing of Caenorhabditis elegans, (v) stimulated the expression of proinflammatory cytokines and was more rapidly cleared in a murine peritoneal infection model. Collectively, our observations imply that ppGpp-mediated signaling in EPEC is important for regulating the expression of two major virulence factors, BFP and LEE, as well as for optimizing in vivo pathophysiology while EPEC survives passage through diverse GIT environments during a host infection.
  • Joong-Yeon Heo

    Professor, Ajou University

    Topic

    • Current Status of Q fever and the Challenge of Outbreak Preparedness in Korea : One Health Approach to Zoonoses

    Summary

Closing

Closing Remarks

  • Hee-Chang Jang

    Director,
    Korea National Institute of Infectious Diseases, KNIH, KDCA

    Education

    • 2017 Chonnam National University, Ph.D
    • 2005 Seoul National University College of Medicine, M.M.Sc
    • 2000 Seoul National University College of Medicine, M.D.

    Experience

    • 2023 ~ Present Director, Korea National Institute of Health
    • 2020 ~ 2023 Director, Department of Precision Medicine, KNIH
    • 2018 ~ 2020 Director, Center for Genome Science, KNIH
    • 2017 ~ 2018 Director, Division of Cardiovascular Diseases, KNIH, KCDC
    • 2012 ~ 2023 PI, National Research Program for Women’s Health
    • 2011 ~ 2014 Team leader, National Center for Medical Information and Knowledge TF
    • 2008 ~ 2014 Team leader, Clinical Research Coordination TF
    • 2005 ~ 2017 Director, Division of Cardiovascular & Rare Diseases, KNIH, KCDC
    • 2002 ~ 2003 Research Associate, Duke University Medical Center, USA
    • 2004 ~ 2002 Assistant professor of Cardiology (Dept. of internal medicine)
    • 2000 ~ 2005 Assistant professor of Cardiology (Dept. of internal medicine)
    • 1998 ~ 2000 Assistant professor, Yonsei Cardiovascular Research Institute
    • 1998 ~ 2000 Instructor, Yonsei Cardiovascular Research Institute, Yonsei University College of Medicine
    • 1996 ~ 1998 Research Student, Department of Clinical Pathology, Shimane Medical University, Japan
    • 1995 ~ 1996 Research fellow, Cardiology division, Yonsei Cardiovascular Center, Yonsei University College of Medicine
    • 1990 ~ 1995 Resident, Department of Internal Medicine, Yongdong Severance Hospital